环磷酰胺/环磷酰胺一水合物/Cytoxan,~98%
- 产品编号：C0229
- 中文名称：环磷酰胺/环磷酰胺一水合物/Cytoxan
- 英文名称：Cyclophosphamide monohydrate
- 英文别名:2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
- CAS号:6055-19-2
- 分子式:C7H15Cl2N2O2P · H2O
- 分子量:279.10
- 纯度:~98%
- EC号:200-015-4
- MDL号:MFCD00149395
性能描述
assay 97.0-103.0% (HPLC)
mp 49-51 °C(lit.)
storage temp. 2-8°C
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
微溶于水，微溶于醇、苯、乙二醇、四氯化碳、二氧六圜，几乎不溶于乙醚及丙酮,失去结晶水即液化，水溶液不稳定,无臭、味微苦。
环磷酰胺是一种细胞毒性物，广泛地用于癌症化疗。它交联DNA，引起DNA链断裂，从而诱发突变。它的临床活性和醛脱氢酶（aldehyde dehydrogenase 1，ALDH1)活性的减少密切相关。
