纳他霉素/游霉素/匹马霉素/Natamycin/Pimaricin,≥95% (HPLC)
- 产品编号：N0101
- 中文名称：纳他霉素/游霉素/匹马霉素/Natamycin/Pimaricin
- 英文名称：Natamycin
- 英文别名:Pimaricin
- CAS号:7681-93-8
- 分子式:C33H47NO13
- 分子量:665.73
- 纯度:≥95% (HPLC)
- EC号:231-683-5
- MDL号:MFCD00135085
订货信息：
产品规格价格(RMB)
- N0101-1G150
- N0101-10G550
- N0101-100G4500
性能描述
| biological source |
from Streptomyces chattanoogensis |
| assay |
≥95% (HPLC) |
| storage temp. |
2-8°C |
Biochem/physiol Actions
An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane3
Application
Pimaricin is an amphoteric macrolide antifungal antibiotic from Streptomyces chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as a ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. Pimaricin is used as a fungicide in agar media. It is used to study the pleitropic regulator AdpAch 1 and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis.
纳他霉素是一种多烯烃大环内酯类抗真菌剂，它对几乎所有的酵母菌和霉菌都有抗菌活性，不仅能够抑制真菌，还能防止真菌霉素的产生。其分子是一种具有活性的环状四烯化合物，含3个以上的结晶水，其外观白色（或奶油色），为无色、无味的结晶粉末，分子式C33H47NO13，分子量为665.73。微溶于水、甲醇，溶于稀酸、冰醋酸及二甲苯甲酰胺，难溶于大部分有机溶剂。在pH值高于9或低于3时，其溶解度会有所提高，在大多数食品的PH范围内非常稳定。纳他霉素具有一定的抗热处理能力，在干燥状态下相对稳定，能耐受短暂高温（100℃）；但由于它具有环状化学结构、对紫外线较为敏感，故不宜与阳光接触。纳他霉素活性的稳定性受PH值、温度、光照强度和氧化剂及重金属的影响，所以产品应该避免与氧化物及硫氢化合物等接触。
