性能描述

生化/生理学作用

Polyether potassium ionophore

使用说明：

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule.1 It has antimicrobial and anticoccidial activities, and is an alkali
ion carrier with affinity for cations, with preference for K+ over other monovalent and divalent cations.Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells.It has been shown tumor cells express elevated levels
of various types of K+ channels, their over expression enhances proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation.4,5 Being a highly selective potassium ionophore Salinomycin may interfere with the function of potassium channels in cancer stem cells (CSCs).5 Established cancer therapies may fail because they kill the bulk tumor cells
but do not eliminate CSCs. Recent studies indicate Salinomycin selectively eradicates breast CSCs.Salinomycin might eliminate CSCs by inducing their
differentiation. Salinomycin was also found to suppress the metastasis of 4T1 cells to the lungs. Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consult the Material
Safety Data Sheet for information regarding hazards and safe handling practices. Preparation Instructions Salinomycin is soluble in methanol (10 mg/ml).
Storage/Stability
Store at 2–8 °C, desiccated and protected from light.Stable for 3 years under these conditions

性状：白色或淡黄色结晶性粉末；微有特异臭味。在甲醇、乙醇、丙酮、乙醚、氯仿中易溶，在正己烷中微溶，在水中不溶。

相关知识：

盐霉素的活性在于它能够和病原微生物及球虫细胞外的阳离子，尤其是K+和Na+形成络合物，然后再通过细菌或细胞膜上的“膜转运蛋白”不断将阳离子送入细胞内，破坏细胞膜内外的离子平衡，使细胞失活，达到抗球虫的目的。

盐霉素为一元羧酸聚醚类动物专用抗生素，对大多数革兰氏阳性菌和各种球虫有较强的抑制和杀灭作用，不易产生耐药性和交叉抗药性，排泄迅速，残留量极低，用于猪可防治腹泻、促生长、提高成活率，主要用于家禽防球虫美国研究人员发现一种可以“瞄准”并杀死癌症干细胞的化合物，在实验室研究期间，其杀死小鼠身上乳腺癌干细胞的效力比普通抗癌药物泰克索（Taxol）高100倍。盐霉素不仅能杀死小鼠身上的乳腺癌干细胞，还能抑制它们生出新的肿瘤细胞，同时还能减缓已经存在的肿瘤的生长速度。