还原型谷胱甘肽/L-还原型谷胱甘肽/Glutathione reduced/GSH,≥98.0%
- 产品编号：G0109
- 中文名称：还原型谷胱甘肽/L-还原型谷胱甘肽/Glutathione reduced/GSH
- 英文名称：L-Glutathione reduced
- 英文别名:γ-L-Glutamyl-L-cysteinyl-glycine, GSH
- CAS号:70-18-8
- 分子式:H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
- 分子量:307.32
- 纯度:≥98.0%
- EC号:200-725-4
- MDL号:MFCD00065939
订货信息：
产品规格价格(RMB)
- G0109-5G95
- G0109-25G390
- G0109-100G1450
性能描述
| 试剂级别 |
生化试剂，可用于细胞培养 |
| assay |
≥98.0% |
| total impurities |
≤0.005% Phosphorus (P) |
| |
≤0.1% Insoluble matter |
| ign. residue |
≤0.1% |
| mp |
192-195 °C (dec.)(lit.) |
| solubility |
H2O: soluble0.1 M at 20 °C, clear, colorless |
| anion traces |
sulfate (SO42-): ≤0.05% |
Application
May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Biochem/physiol Actions
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
还原型谷胱甘肽（GSH）是人类细胞质中自然合成的一种肽，由谷氨酸、半胱氨酸和甘氨酸组成，含有巯基（－SH），广泛分布于机体各器官内，为维持细胞生物功能已呈有重要作用。它是甘油醛磷酸脱氢酶的辅基，又是乙二醛酶及丙糖脱氢酶的辅酶，参与体内三羧酸循环及糖代谢。能激活多种酶【如巯基(-SH)酶等】，从而促进糖、脂肪及蛋白质代谢，并能影响细胞的代谢过程.
