IBMX/3-异丁基-1-甲基黄嘌呤/3-Isobutyl-1-methylxanthine,≥99% (HPLC)
- 产品编号：I0103
- 中文名称：IBMX/3-异丁基-1-甲基黄嘌呤/3-Isobutyl-1-methylxanthine
- 英文名称：3-Isobutyl-1-methylxanthine
- 英文别名:1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
- CAS号:28822-58-4
- 分子式:C10H14N4O2
- 分子量:222.24
- 纯度:≥99% (HPLC)
- EC号:249-259-3
- MDL号:MFCD00005584
订货信息：
产品规格价格(RMB)
- I0103-25MG150
- I0103-100MG390
- I0103-250MG680
- I0103-1G1710
性能描述
| 试剂纯度 |
≥99% (HPLC) |
| form |
powder |
| color |
white to off-white |
| mp |
200-201 °C(lit.) |
| solubility |
DMSO: soluble1 M (with gentle warming) |
| |
ethanol: soluble10 mg/mL |
| storage temp. |
−20°C |
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.
用途： cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶，cAMP的增加激活了PKA ，其结果是减少增殖，增加分化和诱发凋亡. IBMX抑制由苯肾上腺素诱导的色胺（来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM）的减少 。也作为腺苷受体拮抗剂。
贮存： 储存温度： -20°C
质量标准: 外观Appearance 白色至浅灰色蓬松结晶粉末
红外光谱鉴定Infrared spectrometry 和对照品匹配
熔点Melting point 200°C - 203°C
纯度Purity >99.0% (GC)
DMSO溶解性性实验Solubility in DMSO 1 M，溶液透明
醇溶性实验Solubility in ethanol 10 mg/mL
别名： 1-Methyl-3-isobutylxanthine 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
性状： 几乎不溶于水,溶于乙醇,2-丙醇。
熔点: 200-203℃
