O-三环[5.2.1.02,6]癸-9-基二硫代碳酸钾盐/D609,≥95%
- 产品编号：T0112
- 中文名称：O-三环[5.2.1.02,6]癸-9-基二硫代碳酸钾盐/D609
- 英文名称：O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
- 英文别名:D609
- CAS号:83373-60-8
- 分子式:C11H15KOS2
- 分子量:266.46
- 纯度:≥95%
- EC号:280-379-9
- MDL号:MFCD00171401
性能描述
| 试剂纯度 |
≥95% |
| form |
solid |
| color |
off-white to yellow |
| solubility |
H2O: soluble50 mg/mL |
Biochem/physiol Actions
Phosphatidylcholine-specific phospholipase C (PLC) and HIV-1 inhibitor. Xanthogenate derivative with in vitro anti-tumor activity.
Caution
The product is readily soluble in water. However it is very labile in solution (1.5 days half-life in tissue culture medium) and is readily hydrolyzed below pH 6.0. Prepare solutions immediately before use. Discard the unused solution. For tissue culture preparations, the media should be buffered to pH 6.0-7.5. HEPES buffer must not be used as it renders this product toxic.
General description
For tissue culture preparations, the media should be buffered at pH 6.0 to 7.4. HEPES buffer must not be used as it renders this product toxic.
Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity.
Alternative Name: Tricyclodecan-9-yl xanthogenate . K
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. We recommend to prepare fresh solutions each day.
