性能描述

Application
Recommended for use in cell culture applications at 100 mg/L. Stock solutions should be sterile-filtered and stored at 2-8 °C for up to a month or at −20 °C for extended periods. Solutions are stable at 37 °C for 3 days.

Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

用途：属氨基糖苷类，主要抗革兰氏阴性菌，对大肠杆菌和金黄色葡萄球菌有良好的抗菌作用，主要作用于细菌蛋白的合成过程，能使细菌合成异常蛋白，阻碍合成蛋白的释放，使细菌细胞壁膜通透性能增强而导致重要物质外泄死亡。