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羟乙基-β-环糊精/(2-Hydroxypropyl)-β-cyclodextrin/HE-β-CD,98%

  • 产品编号:C0142
  • 中文名称:羟乙基-β-环糊精/(2-Hydroxypropyl)-β-cyclodextrin/HE-β-CD
  • 英文名称:(2-Hydroxypropyl)-β-cyclodextrin
  • 英文别名:Hydroxyethyl-β-cyclodextrin/HE-β-CD
  • CAS号:128446-35-5
  • 纯度:98%
  • EC号:420-920-1

订货信息:

产品规格价格(RMB)
  • C0142-25G560
  • C0142-100G1350
  • C0142-250G2200

性能描述

试剂级别   生化试剂,可用于细胞培养
form   powder
extent of labeling   4-10 (determined by NMR)
solubility   H2O: soluble100 mg/mL
suitability   suitable for cell culture

Application
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

General description
Cyclodextrins are cyclic oligosaccharides consisting of 6, 7, or 8 glucopyranose units, usually referred to as α-, β-, or γ-cyclodextrins, respectively. These compounds have rigid doughnut-shaped structures making them natural complexing agents. The unique structures of these compounds owe their stability to intramolecular hydrogen bonding between the C2- and C3-hydroxyl groups of neighboring glucopyranose units. The molecule takes on the shape of a torus with the C2- and C3-hydroxyls located around the larger opening and the more reactive C6-hydroxyl aligned around the smaller opening. The arrangement of C6-hydroxyls opposite the hydrogen bonded C2- and C3-hydroxyls forces the oxygen bonds into close proximity within the cavity, leading to an electron rich, hydrophobic interior. The size of this hydrophobic cavity is a function of the number of glucopyranose units forming the cyclodextrin.

The solubility of natural cyclodextrins is very poor. In the late 1960’s, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.

Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent.

特点及用途:
1、生化试剂用于细胞培养等。

2、在医药中可以提高药物溶解度,生物利用度,使药剂的疗效增加或服用量减少,可以调整或控制药物的释放速度,降低药物毒副作用,增强药物的稳定性,主要应用于口服液,安全度最高。

3、在食品及香料领域,可提高营养分子的稳定性和长效性,可掩盖或矫正食品营养分子的不良气味和口味。

4、在化妆品领域,可降低化妆品中有机型分子对皮肤粘膜组织的刺激,增强物质的稳定性,防止营养成分的挥发、氧化。

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