Strychnine hemisulfate salt/士的宁半硫酸盐/马钱子碱半硫酸盐,98%
- 产品编号：S0122
- 中文名称：Strychnine hemisulfate salt/士的宁半硫酸盐/马钱子碱半硫酸盐
- 英文名称：Strychnine hemisulfate salt
- CAS号:60-41-3
- 分子式:C21H22N2O2 · 1/2H2SO4
- 分子量:383.45
- 纯度:98%
- EC号:200-477-7
- MDL号:MFCD00068328
订货信息：
产品规格价格(RMB)
- S0122-5G320
- S0122-25G900
- S0122-100G2800
性能描述
Biochem/physiol Actions
Convulsant; glycine receptor antagonist not associated with the NMDA receptor.
This product is soluble in water (50 mg/ml), yielding a clear, colorless solution.
Strychnine is is an poisonous alkaloid extract obtained from the dried ripe seeds of Strychnos nux vomica, a small tree of the East Indies. It is obtained as a white crystalline substance, having a very bitter acrid taste,and is used in research as a powerful neurostimulant.
Strychnine is rapidly absorbed from the gastrointestinal tract (mainly from the intestine), nasal passages, or from injection sites and exerts its effects on the central nervous system.This compound causes deepened respiration and decreased stroke volume of the heart through excitation of the vagal center.The olfactory cortex, auditory cortex,somatosensory cortex, and visual cortex are rendered more acute by stimulation of strychnine, respectively on the frontal, temporal, parietal, and occipital lobes of the brain. The action of strychnine also raises
epinephrine levels and thus increases systemic blood pressure by direct stimulation of the sympathetic nervous system on the smooth muscle of the arterioles. This action can be of great value in reducing cardiac failure. The most direct symptoms caused by strychnine are violent convulsions due to the simultaneous stimulation of the motor or sensory
ganglia of the spinal cord. This can be of value during chronic lead poisoning and during surgical shock.Strychnine can also be used as an antidote in chloroform poisoning. It has also been shown to diminish the motile power of leukocytes and may even stop their motion.Strychnine has been shown to be an inhibitory neurotransmitter at strychnine sensitive ionotropic glycineA receptors, classifying this drug as a glycine antagonist. This effect was first demonstrated in
spinal cord membranes and results in the muscular contractions and tetany as a result of glycinergic disinhibition and overexcitation.In addition, strychine has been shown to antagonize the response of retinal ganglion cells to glycine. In all ganglion cells, 10-5 M
strychnine was shown to eliminate the transient inhibitory events which occur at the onset and termination of a light stimulus.
