紫杉醇/Paclitaxel/taxol,≥97% (HPLC)
- 产品编号：T0122
- 中文名称：紫杉醇/Paclitaxel/taxol
- 英文名称：taxol
- 英文别名:5β，20-环氧-1，2α，4，7β，10β，13α-六羟基紫杉烷-11-烯-9-酮-4，10-二乙酸酯-2-苯甲酸酯-13[（2’R，3’S）-N-苯甲酰-3-苯基异丝氨酸酯]
- CAS号:33069-62-4
- 分子式:C47H51NO14
- 分子量:853.92
- 纯度:≥97% (HPLC)
- MDL号:MFCD00869953
订货信息：
产品规格价格(RMB)
- T0122-5MG300
- T0122-25MG1000
- T0122-100MG3000
性能描述
| 来源 |
from Taxus brevifolia |
| 试剂纯度 |
≥97% (HPLC) |
| form |
powder |
| color |
white |
| mp |
213 °C (dec.)(lit.) |
| solubility |
DMSO: soluble50 mg/mL (can be stored frozen for several months) |
| |
H2O: soluble (hydrolyzes) |
| |
ethanol: soluble |
| |
methanol: soluble (undergoes transesterification) |
| 保存温度 |
2-8°C |
用途: 有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。
Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
