冬凌草甲素/冬凌草素/延命草宁/Oridonin/Isodonol,≥98% (HPLC)
- 产品编号：O0103
- 中文名称：冬凌草甲素/冬凌草素/延命草宁/Oridonin/Isodonol
- 英文名称：7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one
- 英文别名:7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one
- CAS号:28957-04-2
- 分子式:C20H28O6
- 分子量:364.43
- 纯度:≥98% (HPLC)
订货信息：
产品规格价格(RMB)
- O0103-5MG90
- O0103-25MG290
- O0103-100MG990
- O0103-20MG标准品300
性能描述
| 试剂纯度 |
≥98% (HPLC) |
| 性状 |
solid |
| 溶解性 |
DMSO: >20 mg/mL |
| |
H2O: insoluble |
| 保存温度 |
2-8°C |
Biochem/physiol Actions
Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.
