性能描述

Application

Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine.

Biochem/physiol Actions

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

性状描述:白色或乳白色结晶性粉末，无臭或几乎无臭，易溶于水，略溶于乙醇
用途说明:一种抗菌磺胺药，诱导CYP3A4表达，以及通过N-乙酰转移酶乙酰化

中文名称 磺胺二甲嘧啶钠 
别名 N-(4,6-二甲基-2-嘧啶基)-4-氨基苯磺酰胺钠盐 ; 2-(对氨基苯磺酰胺基)-4,6-二甲嘧啶钠 ; 2-(对氨基苯磺酰胺基)-4,6-二甲嘧啶钠盐 ; 磺胺二甲嘧啶钠盐[1] ;
英文名称 Sulfamethazine Sodium
英文别名 4-AMINO-N-[4,6-DIMETHYL-2-PYRIMIDINYL]BENZENE-SULFONAMIDE SODIUM SALT ; SULFADIMIDINE SODIUM ; SULFAMETHAZINE SODIUM SALT ; (n(sup1)-(4,6-dimethyl-2-pyrimidinyl)sulfanilamido)-sodiu ; 4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamidmonosodiumsalt ; bovibol ; n(sup1)-(4,6-dimethyl-2-pyrimidinyl)-; sulfanilamidmonosodiumsalt ; saleso dicodella2-p-aminobenzensulfonamido-4,6-dimetil-; pirimidina ; sodiumsulfadimidine ; sodiumsulfametazine ; sodiumsulfamethazine ; sodiumsulfamethiazine ; sodiumsulfamezathine ; sodiumsulphamezathine ; sulfamethazinesodium ; sulmet ; vesadin ; Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-; pyrimidinyl)-, monosodium salt ; SULFADIMIDINE SODIUM(SM2-NA)(NDC:56631-0901) ; SODIUMSULPHAMETHAZINE ;