Thiamphenicol/甲砜霉素/硫霉素/甲砜氯霉素,>98%
- 产品编号：T0124
- 中文名称：Thiamphenicol/甲砜霉素/硫霉素/甲砜氯霉素
- 英文名称：Thiamphenicol
- 英文别名:D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide
- CAS号:15318-45-3
- 分子式:C12H15Cl2NO5S
- 分子量:356.22
- 纯度:>98%
- EC号:239-355-3
- MDL号:MFCD00467983
订货信息：
产品规格价格(RMB)
- T0124-5G200
- T0124-25G600
- T0124-100G1500
性能描述
Application
Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea. It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit. It is used to study chloraniphenicol-thiamphenicol-resistance and the use of fluorinated analogs when resistance is encountered.
Biochem/physiol Actions
Thiamphenicol inhibits mitochondrial protein synthesis of proteins such as cytochrome c oxidase.
性状：白色结晶性粉末；无臭。熔点为163～167℃。
溶解性：在二甲基甲酰胺中易溶，在无水乙醇中略溶，在水中微溶。
用途：甲砜霉素属抑菌剂，可逆性地与细菌核糖体的50S亚基结合，使肽链增长受阻（可能由于抑制了转肽酶的作用），因此抑制了肽链的形成，从而阻止蛋白质的合成，与氯霉素间呈完全交叉耐药。由于甲砜霉素在肝内不与葡萄糖醛酸结合，因此体内抗菌活性较高。该品尚具有较强的免疫抑制作用，较氯霉素约强6倍。
