Netropsin dihydrochloride/纺锤菌素二盐酸盐/Congocidin/Sinanomycin,≥98% (HPLC)
- 产品编号：N0110
- 中文名称：Netropsin dihydrochloride/纺锤菌素二盐酸盐/Congocidin/Sinanomycin
- 英文名称：Netropsin dihydrochloride
- CAS号:1438-30-8
- 分子式:C18H26N10O3 · 2HCl
- 分子量:503.39
- 纯度:≥98% (HPLC)
- MDL号:MFCD00144883
订货信息：
产品规格价格(RMB)
- N0110-5MG1950
- N0110-25MG4200
性能描述
| 生物学来源 | from Streptomyces netropsis |
| 试剂纯度 | ≥98% (HPLC and TLC) |
| form | powder |
| color | faint yellow |
| solubility | H2O: soluble1 mg/mL |
| storage temp. | −20°C |
Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
链霉菌产生的抗生素。溶于水（30mg/ml，80℃；>0.5mg/ml，25℃），不溶于一般有机溶剂，盐酸盐吸湿性强。
含N-甲基吡咯寡肽，结合到dsDNA的富AT序列上，尤其在小的凹槽位点。它保护该区域免受DNase I和内切核酸酶切割，也抑制拓扑异构酶。
打乱细胞分裂周期，延长G期，并使细胞分裂停止在G期。
医药上具有抗细菌、真菌、锥体虫、牛痘病毒、噬菌体等作用。
