性能描述

suitability     suitable for 1694 per US EPA
保存温度        −20°C

Biochem/physiol Actions
Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV.
Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited .
Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, H. influenzae, S. aureus, P. aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice1 and modification of the kinetics of growth of Gram-negative bacteria.

用途：洛美沙星是一种二氟喹诺酸，是人工合成的广谱抗菌素。其抗菌机制细菌DNA螺旋酶的活性，从而抑制细菌DNA的合成。
洛美沙星属氟喹诺酮类，体外抗菌作用与诺氟沙星相似，较环丙沙星略差，但其体内抗菌活性，包括对大肠杆菌、肺炎杆菌、绿脓杆菌和金葡菌的作用均明显优于诺氟沙星。作用机制同诺氟沙星。
诺氟沙星等喹诺酮类可抑制茶碱类、咖啡因和口服抗凝剂（华法林）在肝脏的代谢，使上述药物因代谢减少而血药浓度升高，致不良反应易于发生。