性能描述

suitability   suitable for 1694 per US EPA

Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

Application
Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 and to study automated luminescence-based cytochrome P450 profiling.

白色或类白色的结晶或结晶性粉末；无臭或几乎无臭。该品在甲醇中略溶，在氯仿或乙醇中微溶，在水或乙醚中不溶。熔点为178 ～184 ℃，熔融时同时分解。