还原型辅酶I/NADH二钠盐/β-DPNH/β-NADH/DPNH,≥97% (HPLC)
- 产品编号：N0118
- 中文名称：还原型辅酶I/NADH二钠盐/β-DPNH/β-NADH/DPNH
- 英文名称：Diphosphopyridine nucleotide, reduced form
- 英文别名:β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate
- CAS号:606-68-8 (anhydrous)
- 分子式:C21H27N7Na2O14P2 · xH2O
- 分子量:709.40 (anhydrous basis)
- 纯度:≥97% (HPLC)
- EC号:210-123-3
- MDL号:MFCD03791273
订货信息：
产品规格价格(RMB)
- N0118-250MG100
- N0118-1G350
- N0118-5G1300
性能描述
| 试剂纯度 | ≥97% (HPLC) |
| | ≥97% (spectrophotometric assay) |
| storage temp. | −20°C |
Biochem/physiol Actions
NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Application
β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
