阿昔洛韦/无环鸟嘌呤/无环鸟苷/阿昔洛维/Acycloguanosine,≥99% (HPLC)
- 产品编号：A0169
- 中文名称：阿昔洛韦/无环鸟嘌呤/无环鸟苷/阿昔洛维/Acycloguanosine
- 英文名称：Acycloguanosine
- 英文别名:9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir
- CAS号:59277-89-3
- 分子式:C8H11N5O3
- 分子量:225.20
- 纯度:≥99% (HPLC)
- EC号:261-685-1
- MDL号:MFCD00057880
订货信息：
产品规格价格(RMB)
- A0169-1G150
- A0169-10G800
- A0169-100G3900
性能描述
| 试剂纯度 | ≥99% (HPLC) |
| form | powder |
| color | white |
| 溶解性 | H2O: soluble0.7 mg/mL |
| | 1 M HCl: soluble50 mg/mL |
| | DMSO: soluble7 mg/mL |
| abs. | ε1mM/256 nm 11.8 |
Biochem/physiol Actions
Antiviral agent. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase.
Antiviral agent. Phosphorylation by herpes simplex virus thymidine kinase (HSV-TK) leads to the formation of acycloguanosine triphosphate that competitively inhibits the viral DNA polymerase. Acycloguanosine can be used to induce apoptosis in cells transfected with HSV-TK. Inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.
Application
Acycloguanosine has been used to study herpes simplex virus latency and reactivation, as well as HIV retrovirus reproduction. Acycloguanosine inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase.
英文名：Aciclovir
中文别名：阿昔洛维、开链鸟嘌呤核苷、开糖环鸟苷、羟乙氧甲鸟嘌呤、适患疗、输维疗静、无环鸟嘌呤核苷、无环鸟嘌呤、无环鸟苷、Acyclovir、Acycloguanosine、ZOVIRAX。
用途：干扰病毒DNA多聚酶，抑制病毒的复制；在DNA多聚酶作用下，与增长的DNA链结合，引起DNA链的延伸中断。 该品对病毒有特殊的亲和力，但对哺乳动物宿主细胞毒性低。体外细胞转化测定有致癌报道，但动物实验未见致癌依据。某些动物实验显示高浓度药物可致突变，但无染色体改变的依据。
