•  提示：此货号为洛伐他汀标准品。

Biochem/physiol Actions 
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. This product is a substrate of Pgp and CYP3A. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. The roles of Pgp and CYP3A, possible connection between drug resistance, regulation of the mevalonate pathway, and iosprenylation of signaling proteins in these observations remain to be resolved. The product induces apoptosis in numerous cancer cell lines perhaps, in part, by inhibiting the isoprenylation of Rho family GTPases. It causes cell cycle arrest in G1 and G2/M phases.

中文别名：洛伐他汀（其他名称：明维欣 洛特 欣露 艾乐汀 洛伐他汀胶囊 洛伐他汀片 洛伐他汀颗粒 雪庆 洛伐他汀分散片 苏欣 海立片 都乐 脉温宁 美维诺林 美降之 乐瓦停 洛凡司丁 罗伐他丁 洛伐他丁 乐福欣 罗华宁 海立 海立之 洛之达 苏尔清 俊宁 乐活 英文别名：2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid, 6-α-Methylcompactin, Lovastatin, Monacolin K,Deolip Lovacor Lovalip Nergadow Mevinolin Mevlor Mexet Sivlor Lovastatin Capsules Lovastatin Dispersible Tablets Lovastatin Granules Lovastatin Tablets Mevacor Mevicor Mevinacor Mevindin Monacolin K Lovastatinum）

化学名称：(S)-2-甲基丁酸-(1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-六氢-3,7-二甲基-8-{2-[(2R,4R)-4-羟基-6氧代-2-四氢

洛伐他汀在体内竞争性地抑制胆固醇合成过程中的限速酶羟甲戊二酰辅酶A还原酶，使胆固醇的合成减少，也使低密度脂蛋白受体合成增加，主要作用部位在肝脏，结果使血胆固醇和低密度脂蛋白胆固醇水平降低，还降低血清甘油三酯水平和增高血高密度脂蛋白水平。