胶原蛋白II型/Collagen Type II/来源于牛鼻膜/SIGMA C7806,100%
- 产品编号：C01670
- 中文名称：胶原蛋白II型/Collagen Type II/来源于牛鼻膜/SIGMA C7806
- 英文名称：Collagen Type II
- CAS号:9007-34-5
- 纯度:100%
- EC号:232-697-4
- MDL号:MFCD00130825
订货信息：
产品规格价格(RMB)
- C01670-5MG800
- C01670-10MG1400
性能描述
| 性状 | 白色冻干粉 |
| 溶解性 | aqueous acid: soluble |
| 保存温度 | 2-8°C |
Preparation Note
An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution.
Collagen Type II is a triple helix composed of three α1(II) strands.
Application
Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.
Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.
