细胞色素C/细胞色素丙/细丙/Cytochrome C,≥96%
- 产品编号：C0170
- 中文名称：细胞色素C/细胞色素丙/细丙/Cytochrome C
- 英文名称：Cytochrome C
- 英文别名:Cytochrome C from bovine heart,Cytochrome C from equine heart
- CAS号:9007-43-6
- 分子式:232-700-9
- 纯度:≥96%
- MDL号:MFCD00130890
订货信息：
产品规格价格(RMB)
- C0170-100MG(牛心)350
- C0170-1G(牛心)2300
- C0170-100MG(马心)340
- C0170-1G(马心)1950
性能描述
| 试剂纯度 | ≥96% based on Mol. Wt. 12,327 basis |
| mol wt | mol wt 12327 Da |
| 保存温度 | −20°C |
Biochem/physiol Actions
The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen.
Application
Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.
生物氧化过程中的电子传递体。其作用原理为在酶存在的情况下，对组织的氧化、还原有迅速的酶促作用。通常外源性细胞色素C不能进入健康细胞，但在缺氧时，细胞膜的通透性增加，细胞色素C便有可能进入细胞及线粒体内，增强细胞氧化，能提高氧的利用。
有关细胞凋亡的研究表明，细胞色素C与细胞凋亡有关，从线粒体中泄露出的细胞色素C有诱导细胞凋亡的作用。
