花生四烯酸/二十碳四烯酸/花生油烯酸/ARA(液体),≥99% (GC)
- 产品编号：A0180
- 中文名称：花生四烯酸/二十碳四烯酸/花生油烯酸/ARA(液体)
- 英文名称：Arachidonic acid
- 英文别名:Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid, Immunocytophyte
- CAS号:506-32-1
- 分子式:C20H32O2
- 分子量:304.47
- 纯度:≥99% (GC)
- EC号:208-033-4
- MDL号:MFCD00004417
订货信息：
产品规格价格(RMB)
- A0180-10MG(标准品)350
- A0180-10MG(98%试剂)280
- A0180-50MG950
性能描述
| 试剂来源 | 猪肝中提取 |
| 试剂级别 | 生化试剂，分析试剂 |
| 试剂纯度 | ≥99% (GC) |
| form | liquid |
| color | clear colorless to very faintly yellow |
| refractive index | n20/D 1.4872(lit.) |
| bp | 169-171 °C/0.15 mmHg(lit.) |
| mp | −49 °C(lit.) |
| solubility | absolute ethanol: soluble10 mg/mL |
| density | 0.922 g/mL at 25 °C(lit.) |
| suitability | suitable for cell culture |
| shipped in | dry ice |
| storage temp. | −20°C |
Biochem/physiol Actions
Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
花生四烯酸，是全顺式-5，8，11，14-二十碳四烯酸，化学式如下：CH3(CH2)4(CH=CH-CH2)4(CH2)2COOH，属于不饱和脂肪酸，其中含有四个碳-碳双键，一个碳-氧双键，为高级不饱和脂肪酸。广泛分布于动物界，少量存在于某个种的甘油酯中，也能在甘油磷脂类中找到。与亚油酸、亚麻酸一起被称为必需脂肪酸（essentialfatty acid）。推断它是前列腺素生物合成的起始物之一。
作用：具有兴奋子宫的作用。能延长大鼠妊娠。对胃酸的分泌有抑制活性。
AA在血液、肝脏、肌肉和其他器官系统中作为磷脂结合的结构脂类起重要作用。此外，AA是许多循环二十烷酸衍生物的生物活性物质，如前列腺素E2(PGE2)、前列腺环素（PGI2）、血栓烷素A2(TXA2)和白细胞三烯和C4(LTC4)的直接前体。这些生物活性物质对脂质蛋白的代谢、血液流变学、血管弹性、白细胞功能和血小板激活等具有重要的调节作用。
