性能描述

保存温度：2-8°C

Biochem/physiol Actions
Piperacillin inhibits the final stage of bacterial cell wall biosynthesis at the level of PBP binding.
Piperacillin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Piperacillin may interfere with autolysin inhibitors.

Application
Piperacillin is a semisynthetic, broad-spectrum ureidopenicillin antibiotic. It is derived from ampicillin. It has been used in pharmacokinetic studies in order to optimize antimicrobial therapy in patients with sepsis. It is used to study piperacillin hypersensitivity reactions and to study multidrug-resistant organisms.

性状：白色结晶性粉末；无臭，略有引湿性。本品在甲醇中易溶，以无水乙醇或丙酮中溶解，在水中极微溶解。比旋度 取本品，精密称定，加无水乙醇溶解并稀释成每1ml中含10mg的溶液，依法测定，比旋度为+160度至+178度。

敏感菌：铜绿假单孢菌、大肠埃希菌、变形杆菌、肺炎克雷伯杆菌、淋球菌、不产β－内酰胺酶的沙门菌属、志贺菌属、脆弱类杆菌、肠球菌

不敏感菌：产气杆菌、枸橼酸杆菌、普鲁威登菌和不动杆菌、沙雷菌属、产酶流感嗜血杆菌