甲硝唑/甲硝哒唑/甲硝基羟乙唑/灭滴唑/2-甲基-5-硝基咪唑-1-乙醇,≥99.0%
- 产品编号：M0143
- 中文名称：甲硝唑/甲硝哒唑/甲硝基羟乙唑/灭滴唑/2-甲基-5-硝基咪唑-1-乙醇
- 英文名称：Metronidazole
- 英文别名:2-Methyl-5-nitroimidazole-1-ethanol
- CAS号:443-48-1
- 分子式:C6H9N3O3
- 分子量:171.15
- 纯度:≥99.0%
- EC号:207-136-1
- MDL号:MFCD00009750
订货信息：
产品规格价格(RMB)
- M0143-25G150
- M0143-100G400
性能描述
| 试剂级别 | 分子生物学试剂 |
| impurities | ≤0.0005% Phosphorus (P) |
| | ≤0.1% Insoluble matter |
| ign. residue | ≤0.1% |
| mp | 159-161 °C(lit.) |
| solubility | acetic acid: soluble0.1 M, clear, faintly yellow |
Biochem/physiol Actions
Metronidazole induces DNA strand breaks. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae.
Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.
Application
Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.
甲硝唑为白色或微黄色的结晶或结晶性粉末；片剂为白色或类白色片。有微臭，味苦而略咸。本品在乙醇中略溶，在水或氯仿中微溶，在乙醚中极微溶解。熔点 本品的熔点为159～163℃。吸收系数 取本品，精密称定，加盐酸溶液（9→1000）溶解并定量稀释制成每1ml中允含13μg的溶液，照分光光度法，在277nm的波长处测定吸收度，吸收系数为365～389。
对下列厌氧菌有较好的抗菌作用： ①拟杆菌属，包括脆弱拟杆菌；②梭形杆菌属；②梭状芽胞杆菌属，包括破伤风杆菌；④ 部分真杆菌；⑤消化球菌和消化链球菌等。
