性能描述

Biochem/physiol Actions
Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Application
Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

性状描述：白色或类白色结晶或粉末，无臭无味，遇光色渐变暗，溶于稀盐酸，微溶于乙醇或丙酮，几乎不溶于水，易溶于氢氧化碱溶液(稀盐酸、氢氧化钠溶液)或氨溶液中

具有广谱及较强抗菌活性，对革兰阳性及阴性菌均有抑制作用，可用于脑膜炎双球菌、肺炎球菌、淋球菌、溶加链球菌

作为二氢叶酸合成酶的竞争性抑制剂；达到阻碍叶酸合成的效果。属于磺胺类广谱抗菌药品