苯并芘/苯并芘/BaP/Benzo[a]pyrene/3,4-Benzopyrene,≥96% (HPLC)
- 产品编号：B0003
- 中文名称：苯并芘/苯并芘/BaP/Benzo[a]pyrene/3,4-Benzopyrene
- 英文名称：3,4-Benzpyrene
- 英文别名:Benzo[def]chrysene
- CAS号:50-32-8
- 分子式:C20H12
- 分子量:252.31
- 纯度:≥96% (HPLC)
- EC号:200-028-5
- MDL号:MFCD00003602
性能描述
| assay |
≥96% (HPLC) |
| bp |
495 °C(lit.) |
| mp |
177-180 °C(lit.) |
Application
Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.
