产品描述：

Molecular Formula: (C22H24N2O8 · HCl)2 · C2H6O ·H2O

Molecular Weight: 1025.89

pKa: 3.5, 7.7, 9.5 (20 °C)1

Melting Point: Approximately 201 °C

lmax: 351 nm, 267 nm

Extinction Coefficient: EmM = 13.2 (351 nm), 17.4 (267nm) (10 mM HCl in methanol).

Specific Rotation: -110 (10 mg/ml, 10 mM HCl in methanol).2

Synonym: Doxycycline hydrochloride hemiethanolatehemihydrate.

Doxycycline is a relative of tetracycline reported to be more effective against sensitive organisms.3 Crossresistance is common although some tetracyclineresistantS. aureus respond to doxycycline. It is most often used as a broad spectrum antibiotic and bacteriostatic agent against bacteria. Doxycycline has also been reported to have antiprotozoal properties. It is used in the treatment of chlamydia, rickettsia,mycoplasma, and some spirochete infections, in addition to the standard treatment of Gram positive/negative infections.Doxycycline is often used in culture at a concentration of 0.1 - 12 mg/ml.

溶解方法：

This product is soluble in water (50 mg/ml), yielding a clear, yellow-green solution. Mild warming may be required to fully dissolve the material.This product is also reported to be soluble in methanol, sparingly soluble in ethanol, and insoluble in chloroform or ether.

存储和使用期限

Solutions in sodium chloride or glucose should be used within 48 hours of preparation and protected from direct sunlight.3 Solutions should be stored at 2-8 °C.
For Laboratory Use Only. Not for drug, household or other uses.

相关知识：

为广谱抑菌剂，高浓度时具杀菌作用。许多立克次体属、支原体属、衣原体属、非典型分枝杆菌属、螺旋体也对本品敏感。本品对革兰阳性菌作用优于革兰阴性菌，但肠球菌属对其耐药。其他如放线菌属、炭疽杆菌、单核细胞增多性李斯特菌、梭状芽孢杆菌、奴卡菌属、弧菌、布鲁菌属、弯曲杆菌、耶尔森菌对本品敏感。

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　　主要成分：由土霉素经6α-位上脱氧而得到的一种半合成四环素类抗生素，制品为盐酸盐半乙醇合半水合物。

      性状：常用其盐酸盐，为淡黄色或黄色结晶性粉末；臭，味苦。在水中或甲醇中易溶，在乙醇或丙酮中微溶，在氯仿中不溶。

　　功能：抗菌谱与四环素、土霉素基本相同，体内、外抗菌力均较四环素为强。微生物对该品与四环素、土霉素等有密切的交叉耐药性。口服吸收良好。主要用于敏感的革兰阳性菌和革兰阴性杆菌所致的上呼吸道感染、扁桃体炎、胆道感染、淋巴结炎、蜂窝组织炎、老年慢性支气管炎等，也用于治疗斑疹伤寒、羌虫病、支原体肺炎等。尚可用于治疗霍乱，也可用于预防恶性疟疾和钩端螺旋体感染。