assay    ≥98% (HPLC) 
form    powder 
storage condition    protect from light 
color    white to off-white 
solubility    DMSO: >20 mg/mL 
storage temp.    2-8°C 

Biochem/physiol Actions

PS48 is a PDK1 (phosphoinositide-depende​nt protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.