性能描述

Product Description
Molecular Formula: C23H27N3O7 • HCl
Molecular Weight: 493.9
CAS Number: 13614-98-7
Synonyms: [4S-(4α,4aα5,5aα,12aα)]-4,7-bis(dimethylamino)-14,4a,5,5a,6,11,12aoctahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-dimethylamino-6-demethyl-6-deoxytetracycline Minocycline is a semi-synthetic tetracycline derivative that has a spectrum of antibacterial activity similar to tetracycline. It is active against streptococci,enterobacteria, and some mycobacteria, and also against such species as Staphylococcus aureus,Neisseria meningitidis, Acinetobacter, Bacteroides,Haemophilus, and Nocardia. Minimum inhibitory concentrations (MIC) can range from 0.06 - 1 μg/ml for the most sensitive organisms, and from 4 - 12.5 μg/ml for moderately sensitive organisms.1,2 A detailed review of minocycline has been published. Minocycline has been shown to inhibit tumor growth in transgenic mice, in combination with AGM-1470 and interferon α/β.4 Minocycline has also been demonstrated to inhibit angiogenesis in rabbit cornea in the presence of the VX2 carcinoma.5 The inhibitory activity of minocycline against several metalloproteinases has been studied. An HPLC assay for the analysis of minocycline in serum and tissue has been published.
Preparation Instructions
This product is soluble water (50 mg/ml), with heat as needed, yielding a clear, yellow to amber solution. It is also soluble in DMSO (7 mg/ml).
Storage/Stability Stock solutions of this product (1 mg/ml, 0.1 N HCl)
may be stored for two days at 4 °C.

相关信息：

【别名】米诺环素、盐酸米诺环素、二甲胺四环素、米诺四环素,美满霉素

【外文名】Minocycline, Minocycline Hydrochloride, Minomycin, Ultramycin

【成分】 为半合成的四环素类抗生素。

【性状】 常用其盐酸盐，为黄色结晶性粉末，无臭、味苦、遇光可引起变质。溶解于水，略溶于乙醇，易溶于碱金属的氢氧化物或碳酸盐溶液中。

【药理与应用】为高效、速效、长效的半合成四环素新制剂，抗菌作用为该属中最强，抗菌谱与多西环素相似。作用比四环素强2-4倍，也胜过多西环素、美他环素、土霉素。能克服耐四环素的金黄色葡萄球菌、链球菌、大肠杆菌，金黄色葡萄球菌对本品不易产生耐药性。口服吸收迅速，且不受食物影响，分布广泛，在肝、肾、肺等组织中浓度较高，在脑及脑脊液中浓度比其他四环素族抗生素为高。t1/2=12.6h. 用于尿路、胃肠道、妇科、皮肤、骨髓、眼、耳、鼻、喉部感染及男性淋病。本品尚可用于阿米巴病的辅助治疗。