地西他滨,≥97%
- 产品编号：A0110
- 中文名称：地西他滨
- 英文名称：5-Aza-2′-deoxycytidine
- 英文别名:2′-Deoxy-5-azacytidine, 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Decitabine
- CAS号:2353-33-5
- 分子式:C8H12N4O4
- 分子量:228.21
- 纯度:≥97%
- EC号:219-089-4
- MDL号:MFCD00043011
订货信息：
产品规格价格(RMB)
- A0110-5MG350
- A0110-25MG1200
- A0110-100MG3900
性能描述
| 纯度 |
≥97% |
| solubility |
acetic acid: water (1:1): soluble50 mg/mL |
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by opening the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
地西他滨为目前已知最强的DNA甲基化特异性抑制剂，阻断DNA甲基化可致基因激活与诱导细胞分化。其对L1210的细胞毒作用可为胸苷所加强，是因胸苷可使本品掺入DNA的量增加，从而增加本品对DNA甲基化的抑制作用。本品为S期细胞周期特异性药物。
Preparation Instructions
This product is typically dissolved at 50 mg/ml in 50% acetic acid. This product is also soluble at 50 mg/ml in DMSO or 0.25 mg/ml in water.
