性能描述

assay    98% 
drug control    stupéfiant 
mp    235-238 °C(lit.) 
solubility    methanol: soluble50mg/ml 
Preparation Note
Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.

Application
• Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry1.
• It was used to study interactions of norharman and harman with DNA.
• It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

General description
• Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
• It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures1.
• Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

哈尔满碱（harmane alkaloid）是指果核中含有哈尔满的吲哚系生物碱，大致区分为下列3种：

（1）哈尔马拉生物碱（harmala alkaloid）：为俄国南部及印度出产的红色染料植物Peganumharmala所含有的生物碱，如哈梅灵（二氢骆驼蓬碱=harmaline，用作驱虫药，中枢神经兴奋剂，胺氧化阻抑剂），哈尔明碱（骆驼蓬碱=harmine，C13H12OH2，此种物质投给哺乳类则刺激中枢神经而引起抽搐，但用于两栖类则有麻醉作用。还有降体温作用）等。
 
（2）吴萸胺（evodiamine）和吴茱萸次碱（ruta-ecarpin）含于中药吴茱萸中，具有发汗及促进分娩作用。
 
（3）育亨宾（yohimbine，茜草科的Pausinyst-alia yohinba树皮中所含有的舒血管药物）。