性能描述

form    powder with small lumps 
color    off-white to light brown 
storage temp.    2-8°C 

溶解性：淡灰色粉末，几乎不溶于水，但可在水中分散成均一的悬浮液。是从酵母细胞壁或酵母细胞提取的一种富含葡萄糖甘露糖的多糖。从啤酒糖酵母菌(Saccharomyces cerevisiae)中提取的也被称为酵母聚糖A(zymosan A)。
Biochem/physiol Actions
Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action.

SOLUBILITY/SOLUTION STABILITY:
The product is extremely stable to temperature, since it is subjected to boiling during isolation. It is not soluble in water, but can be suspended uniformly in saline solution.
For the properdin assay, zymosan A is suspended at 1% in 0.15 M sodium chloride, placed in a boiling water bath for one hour, then centrifuged for 30 minutes at 4000 rpm, the supernatant discarded and the
residue suspended evenly in the diluent of choice to the desired concentration. Such suspensions can be maintained at 0-4°C for at least a month, if not contaminated.

用途：可通过激活备解素(properdin)系统而增强机体特定防御作用。它可用于对细胞吞噬作用的测定试剂和吞噬调理剂。此外，它与血清中天然抗体结合，能灭活补体，形成酵母聚糖(zymosan)-抗体(antibody)-补体(complement)的复合物，简称ZAC 142，这简称中的“142”系指补体的三种成分，这ZAC 142能分裂补体第三种成分、使其失活。另外酵母聚糖也被用于备解素的提纯和检测。